The simulation revolves around manipulating a "strong-willed lady" character in real time. Unlike static visual novels, NejicomiSimulator utilizes to ensure all movements, breathing, and reactions are fluid and synchronized with sound effects.

Players use the mouse to control various body parts including the head, torso, breasts, and genitals.

Players earn Gems through daily login bonuses and "climax bonuses" to unlock advanced settings and features. It typically takes about five days of regular play to unlock all settings for free.